Drugs can cause adverse events in a patient. Bone marrow toxicity is one of the most frequent types of drug-induced toxicity. The most serious form of bone marrow toxicity is:         A. Aplastic anemia.      B. Thrombocytosis.      C. Leukocytosis.      D. Granulocytosis.           Correct Answer: A. Aplastic anemia. Aplastic anemia is the result… Read More »

The extent to which drug is absorbed and transported to target tissue is known as:         A. Steady-state accumulation      B. Therapeutic drug levels      C. Bioavailability      D. Distribution           Correct Answer: C. Bioavailability Bioavailability is the extent to which a drug is absorbed and transported to target tissue. Bioavailability refers… Read More »

A 17-year-old client is taking phenytoin (Dilantin) for the treatment of seizures. Phenytoin blood level reveals to be 25 mcg/ml. Which of the following symptoms would be expected as a result of the laboratory result?         A. No symptoms, because the value is within the normal range.      B. Hyperactivity.      C. Tremors.      D.… Read More »

An order is written to start an IV on a 74-year-old client who is getting ready to go to the operating room for a total hip replacement. What gauge of catheter would best meet the needs of this client?         A. 18      B. 20      C. 21 butterfly      D. 25           Correct… Read More »

The physician orders an intramuscular injection of Demerol for the postoperativepatient’s pain. When preparing to draw up the medication, the nurse is careful to remove the correct vial from the narcotics cabinet. It is labeled         A. Simethicone.      B. Albuterol.      C. Meperidine.      D. Ibuprofen.           Correct Answer: C. Meperidine.… Read More »

Kent, a new staff nurse asks her preceptor nurse how to obtain a blood sample from a patient with a portacath device. The preceptor nurse teaches the new staff nurse:         A. The sample will be withdrawn into a syringe attached to the Portacath needle and then placed into a vacutainer.      B. Portacath devices… Read More »

Serious adverse effects of oral contraceptives include:         A. Increase in skin oil followed by acne.      B. Headache and dizziness.      C. Early or mid-cycle bleeding.      D. Thromboembolic complications.           Correct Answer: D. Thromboembolic complications. Oral contraceptives have been associated with an increased risk of stroke, myocardial infarction, and deep… Read More »

Drug distribution is affected by which of the following?         A. Biotransformation      B. Excretion      C. Protein binding      D. Lipid binding           Correct Answer: C. Protein binding Distribution depends on protein binding as well as circulation. Some drugs leave the bloodstream very slowly because they bind tightly to proteins circulating… Read More »

A client is prescribed with carbamazepine (Tegretol) for the treatment of bipolar disorder. Which of the following laboratory results indicates that the client is experiencing a side effect of this medication?         A. Neutrophil count of 1,200/mm3.      B. Platelet count of 160,000/mm3.      C. Uric acid level of 4mg/dl.      D. SGPT (ALT) level… Read More »