A nurse is reviewing a patient’s medication during shift change. Which of the following medications would be contraindicated if the patient were pregnant? Select all that apply.
A. Warfarin (Coumadin)
B. Finasteride (Propecia, Proscar)
C. Celecoxib (Celebrex)
D. Clonidine (Catapres)
E. Transdermal nicotine (Habitrol)
F. Clofazimine(Lamprene)
Correct Answer: A. Warfarin (Coumadin); B. Finasteride (Propecia, Proscar)
Option A: Warfarin (Coumadin). Has a pregnancy category X and associated with central nervous system defects, spontaneous abortion, stillbirth, prematurity, hemorrhage, and ocular defects when given anytime during pregnancy and fetal warfarin syndrome when given during the first trimester.
Option B: Finasteride (Propecia, Proscar). Also has a pregnancy category X which has a high risk of causing permanent damage to the fetus.
Option C: Celecoxib (Celebrex). Large doses cause birth defects in rabbits; Pregnancy category C.
Option D: Clonidine (Catapres). Crosses the placenta but no adverse fetal effects have been observed.
Option E: Transdermal nicotine (Habitrol). Nicotine replacement products have been assigned to pregnancy category C (nicotine gum) and category D (transdermal patches, inhalers, and spray nicotine products).
Option F: Clofazimine (Lamprene). Clofazimine has been assigned to pregnancy category C.