Which of the following drugs would be ordered by the physician to improve the platelet count in a male client with idiopathic thrombocytopenic purpura (ITP)?
A. Acetylsalicylic acid (ASA)
B. Corticosteroids
C. Methotrexate
D. Vitamin K
Correct Answer: B. Corticosteroids
Corticosteroid therapy can decrease antibody production and phagocytosis of the antibody-coated platelets, retaining more functioning platelets.
Option A: ASA blocks prostaglandin synthesis. Inhibition of COX-1 results in the inhibition of platelet aggregation for about 7-10 days (average platelet lifespan).
Option C: Methotrexate inhibits enzymes responsible for nucleotide synthesis which prevents cell division and leads to anti-inflammatory actions. It causes thrombocytopenia.
Option D: Vitamin K is used to treat an excessive anticoagulate state from warfarin overload.